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Book Description: How old is the AIDS virus (HIV 1) and where did it come from? Is it the result of a recombinant event in simian immunodeficiency viruses (SIVs)? Why do SIVs naturally occur in a variety of nonhuman African primates without inducing AIDS in their natural hosts? HIV 1 has devastated human society, although chimpanzees carry an SIV that is genetically almost identical to HIV 1 but causes no known illness in these great apes. How are Chimpanzees immune to HIV 1? Can humans acquire this immunity? Why do most newborns infected with HIV 1 in utero or during birth become long term non progressors while 20 rapidly develop AIDS and die in less than a year? Why are some adults asymptomatic for over 10 years after infection? Dr. Omar Bagasra, an eminent molecular biologist, immunologist, and retrovirologist, has considered these puzzling questions for more than a decade and now offers intriguing new possibilities for the nature of human immunity and the development of an effective AIDS vaccine. This book is a provocative personal treatise on the origin, evolution and etiology of HIV 1 supported by a wealth of peer reviewed scientific references. The compelling ideas presented in this volume will have an important bearing on HIV vaccine development and current lentiviral gene therapy protocols. It is a must read for anyone interested in the development of a safe AIDS vaccine.

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