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Genetic Disorders of Endocrine Neoplasia (Frontiers of Hormone Research)
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Binding: Hardcover, 1 edition, 200 pages
Publisher: S. Karger AG (Switzerland)
List Price: USD $239.25
ISBN 10: 3805572034
ISBN 13: 9783805572033
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Book Description:
The genetics of endocrine cancers is clearly an area where new scientific discoveries that have occurred in the past few years have already been translated into clinical practice. This volume attempts to provide a state of the art review of some of the most relevant inherited syndromes that share a higher susceptibility to the development of endocrine tumors. It focuses on familial tumor syndromes for which the primary gene defect has been well characterized or recently identified. An overview of cloning strategies and gene characterization in cancer, is combined with detailed discussions of clinical aspects and molecular features of heritable endocrine neoplastic diseases, such as MEN1 and MEN2 and Von Hippel Lindau disease. Studies on the PTEN gene, the first known phosphatase to lead to cancer when disrupted are discussed in detail. Also included disrupted is the recent identification and partial characterization of one of at least two genes for Carney Complex, PRKARIA.

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